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KMID : 0882420140870050625
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Korean Journal of Medicine
2014 Volume.87 No. 5 p.625 ~ p.629
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Glucocorticoid Triggers an Attack of Periodic Hypokalemic Paralysis during Treatment for Diffuse Large B-cell Lymphoma
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Ha Kyung-Sun
Park Young-Jae
Park Sung-Soo
Lee Joon-Yub
Kim Ji-Hyun
Jang In-Ae
Byeon Jae-Ho
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Abstract
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Hypokalemic periodic paralysis is a rare disorder characterized by sudden onset of weakness and low serum potassium levels. We report a case provoked by combination chemotherapy including prednisolone. A 23-yr-man, diagnosed with diffuse large B-cell lymphoma, received chemotherapy. He developed significant weakness in upper and lower extremities during chemotherapy, and his serum potassium level was 1.7 mmol/L. Potassium replacement restored the weakness. Further workup revealed that prednisolone had provoked hypokalemic paralysis. As prednisolone triggered an attack of hypokalemic periodic paralysis, it should be administered with caution, particularly in patients with periodic paralysis.
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KEYWORD
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Hypokalemic periodic paralysis, Diffuse large B-cell lymphoma
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